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Updated: Dec 25, 2025

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics
Published on: September 14, 2015
Elevated p38MAPK activity promotes neural stem cell aging
Leire Moreno-Cugnon1, Olatz Arrizabalaga1, Irantzu Llarena2
1Biodonostia Health Research Institute, Group of Cellular Oncology, San Sebastian, Spain.
Abstract:
Age-progressive neural stem cell (NSC) dysfunction leads to impaired neurogenesis, cognitive decline and the onset of age-related neurodegenerative pathologies. p38MAPK signalling pathway limits stem cell activity during aging in several tissues. Its role in NSCs remains controversial. In this work, we show that p38MAPK activity increases in NSCs with age in the subventricular zone (SVZ) and its pharmacological inhibition is sufficient to rejuvenate their activity in vitro. These data reveal a cell-autonomous role for p38MAPK increase in decreasing NSC homeostasis with age. This information shed light in the role of p38MAPK in NSC aging.
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