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Chloroquine enhances the cytotoxicity of cis-diamminedichloroplatinum II
1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Cancer Biochemistry Biophysics
|July 1, 1988
Abstract:
A low dose (10 microM) of the antitumor drug cis-diamminedichloroplatinum II (cDDP) was not found to be cytotoxic to HeLa S3 cells in culture in this study, as observed by Roberts and Fraval (1978). The cytotoxicity of this nontoxic dose of cDDP, can be greatly enhanced by treating cells with 200 microMs chloroquine immediately after exposure to the platimum drug.