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Diagnostic value of pentraxin 3 in respiratory tract infections: A meta-analysis

Wu Ye1, Qing-Dong Huang, Ting-Yu Tang

  • 1Department of Respiratory Diseases, Zhejiang Hospital, Hangzhou, Zhejiang Province, People's Republic of China.

Medicine
|April 4, 2020
PubMed
Abstract

Insights

Pentraxin 3 shows moderate accuracy in diagnosing respiratory tract infections and ventilator-associated pneumonia. Bronchoalveolar lavage fluid levels offer superior diagnostic value compared to serum concentrations for these infections.

Area of Science:

  • Biochemistry
  • Medical Diagnostics
  • Infectious Diseases

Background:

  • Pentraxin 3 is an acute phase protein belonging to the long pentraxin subfamily.
  • It plays a role in the innate immune system response to inflammation.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of Pentraxin 3 for respiratory tract infections through a meta-analysis.
  • To compare the diagnostic utility of Pentraxin 3 in different sample types, such as serum and bronchoalveolar lavage fluid (BALF).

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, Web of Knowledge, Cochrane Library).
  • Diagnostic performance metrics including sensitivity, specificity, likelihood ratios, and diagnostic odds ratio were pooled.
  • Summary receiver operator characteristic (SROC) curves and Q* values were calculated to assess overall accuracy.

Main Results:

  • The meta-analysis included 8 studies with 961 participants.
  • Pooled sensitivity and specificity for Pentraxin 3 in diagnosing respiratory tract infections were 0.78 and 0.73, respectively.
  • The area under the SROC curve was 0.84, with higher values for BALF (0.89) compared to serum (0.85). The diagnostic accuracy for ventilator-associated pneumonia (VAP) was 0.89.

Conclusions:

  • Pentraxin 3 demonstrates moderate diagnostic accuracy for respiratory tract infections and VAP.
  • Bronchoalveolar lavage fluid levels of Pentraxin 3 provide superior diagnostic value compared to serum concentrations.
  • Cutoff value was identified as a source of heterogeneity in diagnostic accuracy.

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