Differentiated adipose-derived stem cells promote peripheral nerve regeneration.
Daiki Yamamoto1, Kaoru Tada1, Seigo Suganuma1
1Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Japan.
Muscle & Nerve
|April 4, 2020
Summary
Adipose-derived stem cells (ADSCs) combined with a clinical-grade tube promoted nerve regeneration in rats. Differentiated ADSCs maintained their state and aided nerve repair, showing promise for future therapies.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Neuroscience
Background:
- Adipose-derived stem cells (ADSCs) show potential for nerve regeneration.
- Polyglycolic acid collagen (PGA-c) tubes are clinically approved biomaterials.
Purpose of the Study:
- To investigate nerve regeneration using a combination of PGA-c tubes and Schwann cell-like differentiated ADSCs (dADSCs).
Main Methods:
- Bridging 15-mm sciatic nerve gaps in rats with PGA-c tubes (Group I) or tubes with dADSCs (Group II).
- Comparison with autograft nerve repair (Group III).
Main Results:
- Group II showed greater axonal outgrowth than Group I.
- Nerve conduction latency was similar between Group II and III, but action potential was lower in Group II.
- Transplanted dADSCs retained Schwann cell marker expression.
Conclusions:
- Differentiated ADSCs maintained their phenotype within the PGA-c tubes.
- The combination of dADSCs and PGA-c tubes shows potential for enhancing nerve regeneration.
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