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Updated: Dec 25, 2025
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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
19.7K
Genetics of Postlingual Sensorineural Hearing Loss
Shadi Ahmadmehrabi1,2, Jason Brant3, Douglas J Epstein2
1Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
The Laryngoscope
|April 4, 2020
Summary
Genetic factors play a significant role in adult-onset hearing loss (HL), complementing environmental influences. Understanding these genetic underpinnings is crucial for personalized HL management.
Area of Science:
- Genetics and Audiology
- Molecular Biology
- Clinical Medicine
Background:
- Adult-onset hearing loss (HL) traditionally emphasizes environmental factors like noise and ototoxic drugs.
- Presbycusis is the most common diagnosis, but its onset and progression vary significantly.
- Growing evidence points to gene-environment interactions in adult HL.
Purpose of the Study:
- To review the main concepts of genetics related to adult-onset hearing loss.
- To identify genes implicated in non-syndromic postlingual HL.
- To discuss the clinical implications of genetic findings in HL.
Main Methods:
- Literature review of genetic factors in adult-onset hearing loss.
- Identification of susceptibility loci and specific genes through case reports and GWAS.
- Synthesis of current knowledge on gene-environment interactions.
Main Results:
- Accumulating evidence supports the role of gene-environment interactions in adult HL.
- Specific susceptibility loci for age-related HL have been identified.
- Numerous genes associated with non-syndromic postlingual HL have been discovered.
Conclusions:
- Genetics is a critical component of adult-onset hearing loss, alongside environmental factors.
- Understanding implicated genes can lead to better diagnosis and management strategies.
- Further research into genetic and gene-environment interactions is essential for HL treatment.
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