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Circadian rhythms are suppressed in hyperproliferative mouse epidermis
W R Brown1, R D Furukawa, C A Ramsay
1Department of Medicine, University of Toronto, Ontario, Canada.
Cell and Tissue Kinetics
|May 1, 1988
Abstract:
We examined the chronically hyperproliferative epidermis of the asebia (ab/ab) mouse for circadian rhythms in cell proliferation and in the rate of DNA synthesis, which is related to S phase duration. The curve for the circadian rhythm in cell proliferation for asebia epidermis was suppressed and distorted in comparison to that for BALB/cJ epidermis and in comparison to a composite curve produced by averaging the results from ten other published studies.