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Updated: Dec 25, 2025

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization
Published on: March 16, 2020
Impact of GPCR Structures on Drug Discovery
Miles Congreve1, Chris de Graaf1, Nigel A Swain1
1Sosei Heptares, Steinmetz Building, Granta Park, Abingdon, Cambridge CB21 6DG, UK.
None:
Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of these drug candidates have entered clinical trials. Given the length of time required for a drug to reach the market, there are no documented examples of licensed drugs being developed with the aid of a structure, but this is likely to change as current efforts come to fruition.
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