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Updated: Dec 25, 2025

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
Multiple analyte profiling (MAP) index as a powerful diagnostic and therapeutic monitoring tool
Mahmoud Elsabahy1, Karen L Wooley2, Amy Hendricksen3
1Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, and Laboratory for Synthetic-Biologic Interactions, Texas A&M University, College Station, TX 77842, USA; Science Academy, Badr University in Cairo (BUC), Badr City, Cairo, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, and Assiut International Center of Nanomedicine, Assiut University, Assiut 71515, Egypt.
Abstract:
A robust data mining algorithm is presented as a critical solution to the challenge of managing intensive data generated from the recently developed multiplexing techniques, which allow simultaneous detection of up to 500 biomarkers in a few microliters of a single sample. Furthermore, detailed methodology is provided for exploiting the new algorithm along with examples for description of the first application as a powerful diagnostic and therapeutic monitoring tool in the management of breast cancer, as a disease model.
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