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Roxithromycin and controlled release theophylline, an interaction study.

M Bandera1, M Fioretti, R Rimoldi

  • 1Pneumology Dept., Ospedale Civile, Varese, Italy.

Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
|October 1, 1988
PubMed
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Roxithromycin, a new macrolide antibiotic, does not significantly alter theophylline plasma levels in patients with chronic bronchitis. This finding suggests that roxithromycin can be safely co-administered with controlled-release theophylline formulations.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Respiratory Medicine

Background:

  • Chronic bronchitis management often involves theophylline, a medication requiring careful dosage monitoring.
  • New antibiotics like roxithromycin are being developed, necessitating drug interaction studies.

Purpose of the Study:

  • To investigate potential interactions between roxithromycin and theophylline in patients with chronic bronchitis.
  • To determine if roxithromycin affects theophylline plasma concentrations.

Main Methods:

  • A clinical trial was conducted with 16 male subjects experiencing chronic bronchitis relapse.
  • Theophylline was administered using a controlled-release formulation.
  • Roxithromycin's effect on theophylline plasma levels was assessed.

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Main Results:

  • No clinically significant changes in theophylline blood levels were observed.
  • Roxithromycin did not demonstrate a notable interference with theophylline pharmacokinetics.

Conclusions:

  • Roxithromycin can likely be administered concurrently with controlled-release theophylline.
  • The study supports the simultaneous use of roxithromycin and theophylline in chronic bronchitis patients.