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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
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Current update in domino liver transplantation
Hugo Pinto Marques1, Inês Barros1, Jun Li2
1Hepato-Biliary-Pancreatic and Transplantation Center/ Curry Cabral Hospital, Lisbońs Central Hospitals and University Center, and NOVA Medical School, Lisboa, Portugal.
International Journal of Surgery (London, England)
|April 4, 2020
Summary
Domino liver transplantation (DLT) expands the donor pool by reusing explanted livers for another patient. This complex procedure yields excellent results in experienced centers, offering a vital option for end-stage liver disease patients.
Area of Science:
- Hepatology
- Transplantation Surgery
- Organ Donation
Background:
- Orthotopic liver transplantation is a standard treatment for end-stage liver disease and metabolic disorders.
- A critical shortage of donor livers exists, increasing patient waiting lists.
- Domino liver transplantation (DLT) offers a strategy to increase the available organ supply.
Purpose of the Study:
- To review the current global status and outcomes of domino liver transplantation (DLT).
- To highlight DLT as a method for expanding the donor pool in liver transplantation.
Main Methods:
- This review synthesizes current data on DLT procedures worldwide.
- Analysis focuses on surgical and logistical aspects of DLT.
- Outcomes in experienced, high-volume transplant centers are examined.
Main Results:
- DLT utilizes the explanted liver from one recipient as a graft for a second patient.
- Despite surgical and logistical challenges, DLT has demonstrated excellent outcomes.
- Success is strongly associated with experienced, high-volume transplantation centers.
Conclusions:
- Domino liver transplantation is a viable and effective strategy to expand the donor liver pool.
- Careful patient selection and experienced surgical teams are crucial for successful DLT outcomes.
- DLT represents an important advancement in managing organ shortages for liver transplantation.
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