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Updated: Dec 25, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Do early parental postnatal depression, attachment style and perceived social support affect neurodevelopmental
Tuba Çelen Yoldaş1, Hasan Tolga Çelik2, Gökçenur Özdemir1
1Hacettepe University Faculty of Medicine, Department of Pediatrics, Division of Developmental and Behavioral Pediatrics, Ankara, Turkey.
Insights
Parental mental health impacts premature infant development. Fathers' depression affected cognitive skills, while mothers' anxious attachment influenced language development in preterm infants.
Area of Science:
- Neonatal development
- Perinatal mental health
- Parental psychology
Background:
- Premature birth is stressful, increasing parental postnatal depression (PND) risk.
- Mothers may experience delayed attachment due to medical factors.
- Social support is crucial, but paternal factors are understudied.
Purpose of the Study:
- To assess the impact of parental PND, attachment style, and social support on premature infant development.
- To consider prematurity degree and risk groups in the analysis.
- To identify specific parental factors influencing neurodevelopmental outcomes.
Main Methods:
- Prospective study of 96 preterm infants.
- Parents completed EPDS, AASS, and MSPSS at 3 months corrected age.
- Infant development assessed using Bayley III at 6 and 18 months corrected age.
Main Results:
- Mothers reported higher PND than fathers; attachment and social support were similar.
- Fathers' depression inversely correlated with cognitive development (p=0.030).
- Mothers' anxious/ambivalent attachment inversely correlated with language development (p=0.011) at 6 months.
Conclusions:
- Parental well-being is critical for improving premature infant outcomes.
- Interventions should address fathers' depressive symptoms.
- Maternal anxious/ambivalent attachment also requires attention for better infant development.
Background:
The birth of a premature infant is both a stressful event for both parents and associated with an increased rate of postnatal depression (PND). Additionally some mothers may have delayed feelings of attachment to their babies because of the medical procedures or possible medical complications. Social support is known as an important factor for well-being in the postnatal period. However there is scarce data about these factors for fathers. We aimed to identify the impact of parental PND, attachment style and social support on premature infant development considering the prematurity degree and risk groups.
Methods:
This prospective study was conducted by including 96 infants who were born preterm. Mothers and fathers were given Edinburgh Postnatal Depression Scale (EPDS), Adult Attachment Style Scale (AASS), and Multidimensional Scale of Perceived Social Support (MSPSS) to fill out when their infants' corrected age was 3 months. The developmental evaluation was conducted with Bayley III at the corrected 6 months and 18 months of age.
Results:
Postnatal depression scores were more in mothers than fathers, the rates of secure attachment and social support were similar between mothers and fathers. Factors associated with the neurodevelopmental outcomes including prematurity degree and risk groups, EPDS, AASS and MSPSS scores were analyzed for both parents. In multivariate analysis, fathers' depression scores were inversely associated with cognitive development (p = 0.030, R2 = 0.080, B=-0.283) and mothers' anxious/ambivalent attachment style was inversely associated with language development (p = 0.011, R2 = 0.108, B=-0.329) at the age of corrected 6 months old.
Conclusions:
Our findings underscore that the efforts to improve developmental outcomes of premature infants should include parental well-being taking into account new fathers' depressive symptomatology and maternal anxious/ambivalent attachment.
Related Concept Videos
Relationship with Parents: Attachment
Socioemotional Development during Infancy
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Attachment
Attachment Styles
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