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Platelet-Leukocyte Interplay in Cancer Development and Progression
Dagmar Stoiber1,2, Alice Assinger1
1Department of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Cells
|April 5, 2020
Summary
Platelets, beyond blood clotting, significantly influence cancer by interacting with immune cells. This review details how platelet-leukocyte interactions drive cancer progression, metastasis, and immune evasion.
Area of Science:
- Immunology
- Oncology
- Hematology
Background:
- Platelets are key in hemostasis and increasingly recognized for immune regulation.
- Platelet-leukocyte interactions impact tumor pathology at multiple stages.
- Cancer patients exhibit systemic platelet activation, linked to thrombosis risk.
Purpose of the Study:
- To review the multifaceted role of platelet-leukocyte interactions in cancer development and progression.
- To highlight cancer-associated alterations in platelet and leukocyte functions.
- To elucidate the impact of these interactions on cancer pathology.
Main Methods:
- Literature review focusing on platelet-leukocyte interactions in cancer.
- Analysis of how platelets modulate endothelium, leukocyte recruitment, and inflammatory milieu.
- Examination of platelet influence on innate and adaptive immune responses in cancer.
Main Results:
- Platelets promote angiogenesis, metastasis, and thrombosis in cancer.
- Platelets modulate dendritic cell antigen presentation, monocyte differentiation, and neutrophil extracellular trap formation.
- Platelets influence T-helper cell 17 differentiation and natural killer cell functions, impacting tumor surveillance.
Conclusions:
- Platelet-leukocyte interactions are critical regulators of cancer progression and immune response.
- Altered platelet and leukocyte functions in cancer contribute to pathology, including thrombosis and metastasis.
- Understanding these interactions offers insights into novel cancer therapeutic strategies.
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