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Techniques to Induce and Quantify Cellular Senescence
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Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules

Sara Cruciani1, Giuseppe Garroni1, Giorgio Carlo Ginesu2

  • 1Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.

Biology
|April 5, 2020
PubMed

Insights

Myrtus Communis L. extracts prevent premature cellular senescence caused by oxidative stress. This natural compound helps maintain tissue function by regulating cell cycle markers and promoting cell repair.

Area of Science:

  • Cellular and Molecular Biology
  • Natural Product Chemistry
  • Aging Research

Background:

  • Cellular senescence contributes to age-related diseases and tissue dysfunction.
  • Oxidative stress is a key factor inducing premature senescence.
  • Natural compounds possess antioxidant properties that may counteract cellular damage.

Purpose of the Study:

  • To investigate the potential of Myrtus Communis L. extracts in preventing oxidative stress-induced premature senescence.
  • To evaluate the effect of Myrtus extracts on senescence markers in adipose-derived stem cells (ADSCs).

Main Methods:

  • ADSCs were pre-treated with Myrtus Communis L. extracts.
  • Senescence was induced using hydrogen peroxide (H2O2).
  • Expression of senescence markers (p16, p19, p21, p53, TERT, c-Myc) and beta-galactosidase activity were assessed.

Main Results:

  • Myrtus extracts pre-treatment protected ADSCs from H2O2-induced premature senescence.
  • Extracts modulated cell cycle regulation.
  • Expression of TERT and c-Myc was induced, suggesting a role in cellular repair.

Conclusions:

  • Myrtus Communis L. extracts demonstrate a protective effect against premature cellular senescence.
  • These natural compounds may hold therapeutic potential for diseases associated with aging and tissue degeneration.
  • Further research into natural compounds for anti-senescence therapies is warranted.
Keywords:
cellular mechanismsgene expressionnutraceuticalsoxidative stresssenescencestem cells

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