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Does cortisol inhibit vasopressin secretion in sheep?

C E Wood¹, J Silbiger

¹Department of Physiology, University of Florida College of Medicine, Gainesville.

Domestic Animal Endocrinology

|April 1, 1988

Summary

Cortisol does not inhibit vasopressin secretion in adult sheep, even during hypotension. This suggests developmental or species-specific differences in how glucocorticoids affect vasopressin responses.

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Area of Science:

Endocrinology
Physiology
Neuroscience

Background:

Glucocorticoids are known to inhibit vasopressin release in dogs during stress.
Previous studies in fetal sheep did not demonstrate this glucocorticoid inhibition of vasopressin.
This suggests potential developmental or species-specific influences on the glucocorticoid-vasopressin interaction.

Purpose of the Study:

To investigate if glucocorticoids inhibit vasopressin secretion in adult ewes.
To explore potential developmental or species-specific differences in this physiological interaction.

Main Methods:

Adult ewes received infusions of cortisol or a vehicle control.
Arterial hypotension was induced using sodium nitroprusside to stimulate vasopressin secretion.
Plasma cortisol and vasopressin concentrations were measured.

Main Results:

Cortisol infusions successfully increased plasma cortisol levels in adult ewes.
Arterial hypotension stimulated vasopressin secretion similarly in both cortisol-infused and vehicle-infused groups.
No significant difference in peak plasma vasopressin concentrations was observed between the groups.

Conclusions:

Elevated plasma cortisol concentrations, comparable to stress levels, do not inhibit vasopressin secretion in adult sheep.
The findings support the hypothesis of developmental or species-specific differences in the regulation of vasopressin by glucocorticoids.

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