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Interaction between Epithelial Sodium Channel γ-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in

Ali Sassi1,2, Yubao Wang1,2, Alexandra Chassot1,2

  • 1Department of Cellular Physiology and Metabolism, University of Geneva, University Medical Center, Geneva, Switzerland.

Journal of the American Society of Nephrology : JASN
|April 5, 2020
PubMed
Summary

The gamma subunit of the epithelial sodium channel (ENaC) specifically regulates claudin-8 expression, controlling kidney paracellular permeability. This finding is crucial for understanding sodium reabsorption and preventing solute backflow in the renal collecting duct.

Keywords:
epithelial sodium channelparacellular ion permeabilityprincipal cellsodium reabsorptiontight junction

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