Related Experiment Video
Updated: Dec 25, 2025
10:33
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
3.0K
Vision loss in anterior uveitis.
Haya H Al-Ani1, Joanne L Sims1, Oren Tomkins-Netzer2
1Ophthalmology, Greenlane Clinical Centre, Auckland, New Zealand.
The British Journal of Ophthalmology
|April 5, 2020
Summary
Permanent vision loss from anterior uveitis is uncommon but carries a significant risk, especially in cases of chronic anterior uveitis (CAU) and infectious causes. Uveitic glaucoma is the leading cause of vision impairment.
Area of Science:
- Ophthalmology
- Immunology
- Public Health
Background:
- Anterior uveitis is an ocular inflammatory condition.
- Long-term complications, including vision loss, require thorough investigation.
Purpose of the Study:
- To assess the long-term risk of permanent vision loss in individuals with anterior uveitis.
- Identify key risk factors and common causes of vision impairment in this patient group.
Main Methods:
- Retrospective analysis of 2526 eyes from 1814 patients across two major eye hospitals (2008-2018).
- Follow-up averaged 6.8 years, measuring best-corrected visual acuity (BCVA), moderate vision loss (MVL ≤20/50), and severe vision loss (SVL ≤20/200).
Main Results:
- Permanent vision loss occurred in 3.8% (MVL) and 1.5% (SVL) of eyes.
- Cumulative 10-year risk for MVL was 6.6% and for SVL was 2.6%.
- Uveitic glaucoma, cystoid macular edema, and corneal scars were primary causes of MVL.
Conclusions:
- While uncommon, permanent vision loss from anterior uveitis is a serious concern.
- Chronic anterior uveitis (CAU), infectious etiology, and poor initial BCVA are significant risk factors.
- Uveitic glaucoma is the most frequent cause of vision loss in anterior uveitis patients.
Related Concept Videos
01:25Glaucoma: Overview
1.1K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
01:27Open Angle Glaucoma: Treatment
890
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
890
01:28Angle Closure Glaucoma: Treatment
1.0K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K
01:22Photoreceptors and Visual Pathways
8.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.5K