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β-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis.

Sining Leng1,2, Emanuele Pignatti1,3, Radhika S Khetani4

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Adrenal cortex cells form rosettes, crucial for postnatal development and adult tissue maintenance. This study reveals β-catenin and Fgfr2 regulate rosette formation, impacting adrenal structure and function.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Endocrinology

Background:

  • Rosettes are key in embryonic epithelial morphogenesis.
  • Their function in postnatal development and adult tissue maintenance is largely unknown.
  • The zona glomerulosa of the adrenal cortex is essential for hormone production.

Purpose of the Study:

  • To investigate the role of rosettes in postnatal adrenal development and adult tissue maintenance.
  • To elucidate the molecular mechanisms regulating rosette formation in the zona glomerulosa.
  • To identify key genes involved in adrenal rosette morphogenesis.

Main Methods:

  • Utilized genetic mouse models to study β-catenin function.
  • Analyzed adherens junction dynamics and rosette formation.
  • Investigated the role of Fgfr2 in adrenal rosette development.

Main Results:

  • Zona glomerulosa cells form rosettes via adherens junction-mediated constriction.
  • Loss of β-catenin disrupts rosettes and adrenal structure; stabilization expands glomeruli.
  • Fgfr2 is essential for rosette formation by regulating adherens junctions.

Conclusions:

  • Rosette formation is vital for postnatal adrenal morphogenesis and tissue maintenance.
  • β-catenin and Fgfr2 are critical regulators of adrenal rosette formation.
  • This study provides a framework for understanding zona glomerulosa function.