Related Experiment Video
Updated: Dec 25, 2025
Diffusion Imaging in the Rat Cervical Spinal Cord
Published on: April 7, 2015
Non-Gaussian Diffusion Models and T1 rho Quantification in the Assessment of Hepatic Sinusoidal Obstruction Syndrome
Jian Lyu1,2, Guixiang Yang3,4, Yingjie Mei5
1School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Background:
Non-Gaussian diffusion models and T1 rho quantification may reflect the changes in tissue heterogeneity in hepatic sinusoidal obstruction syndrome (SOS).
Purpose:
To investigate the feasibility of diffusion kurtosis imaging (DKI), stretched exponential model (SEM), and T1 rho quantification in detecting and staging SOS in a monocrotaline (MCT)-induced rat model.
Study Type:
Animal study.
Population:
Thirty male Sprague-Dawley rats gavaged with MCT to induce hepatic SOS and six male rats without any intervention.
Field Strength/Sequence:
3.0T, DWI with five b-values (0-2000 s/mm2 ) and T1 rho with five spin lock times (1-60 msec).
Assessment:
MRI was performed 1 day before and 1, 3, 5, 7, and 10 days after MCT administration. The corrected apparent diffusion coefficient (Dapp ), kurtosis coefficient (Kapp ), distributed diffusion coefficient (DDC), and intravoxel water molecular diffusion heterogeneity (α) were calculated from the corresponding non-Gaussian diffusion model. The T1 rho value was calculated using a monoexponential model. Specimens obtained from the six timepoints were categorized into normal liver (n = 6), early-stage (n = 16), and late-stage (n = 14) SOS in accordance with the pathological score.
Statistical Tests:
Parametric statistical methods and receiver operating characteristic (ROC) curves were employed to determine diagnostic accuracy.
Results:
The Dapp , Kapp , DDC, α, and T1 rho values were correlated with pathological score with r values of -0.821, 0.726, -0.828, -0.739, and 0.714 (all P < 0.001), respectively. DKI (combined Dapp and Kapp ) and SEM (combined DDC and α) were better than T1 rho for staging SOS. The areas under the ROC curve of DKI, SEM, and T1 rho for differentiating normal liver and early-stage SOS were 0.97, 1.00, and 0.79, whereas those of DKI, SEM, and T1 rho for differentiating early-stage and late-stage SOS were 1.00, 0.97, and 0.92, respectively.
Data Conclusion:
DKI, SEM, and T1 rho may be helpful in staging SOS.
Level Of Evidence:
2 TECHNICAL EFFICACY STAGE: 2 J. Magn. Reson. Imaging 2020;52:1110-1121.
