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1,2,3-Triazoles: structural changes on two effective inhibitors of the prostaglandin synthesis in vitro
1Istituto di Chimica Farmaceutica, Università di Pisa, Italy.
Il Farmaco; Edizione Scientifica
|July 1, 1988
Abstract:
This paper describes the synthesis and the biological evaluation of some 1,2,3-triazoles which represent structural modifications of two compounds which are effective inhibitors of the prostaglandin synthesis in vitro. These modifications, concerning the elimination of the methylene bridge and/or the ether oxygen from the active molecules, show that every introduced structural changes caused a strong decrease of activity.