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Infection in infants and children
Abstract:
Infection with Listeria monocytogenes is demonstrated over a 141/2 year period in 24 newborns, three infants 1 to 2 months of age, and two children. Comparison of the 22 cases of Listeria meningitis in newborns with 118 cases of neonatal meningitis due to other bacteria indicates a later onset of symptoms in cases of Listeria meningitis with a more favorable outcome than with most other agents. Treatment with ampicillin sodium appears effective. Monocytic cell increases in peripheral blood or CSF may be helpful in suspecting this diagnosis. The cases of Listeria meningitis in the older children were unusual. In one child it occurred as a concomitant infection with Staphylococcus epidermidis of a ventricular shunt. In the second case in an otherwise healthy child the acquisition of the bacteria from gerbils was suggested, but could not be confirmed.
Insights
Listeria monocytogenes infections in newborns present later and have better outcomes than other bacterial meningitis. Ampicillin sodium shows effectiveness in treatment, with monocytic cell increases aiding diagnosis.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neonatal Care
Background:
- Listeria monocytogenes is a significant pathogen causing meningitis in neonates.
- Neonatal meningitis presents a serious threat with high morbidity and mortality.
Observation:
- A 14.5-year study identified 24 cases of Listeria monocytogenes infection in newborns, infants, and children.
- 22 cases of Listeria meningitis in newborns were compared to 118 cases of meningitis from other bacteria.
Findings:
- Listeria meningitis in newborns typically shows a later onset of symptoms compared to other bacterial meningitis.
- Listeria meningitis in newborns demonstrated a more favorable outcome than meningitis caused by most other bacterial agents.
- Ampicillin sodium treatment appeared effective for Listeria meningitis.
- Elevated monocytic cells in peripheral blood or cerebrospinal fluid (CSF) may suggest Listeria infection.
Implications:
- Early recognition and treatment of Listeria meningitis are crucial for improved patient outcomes.
- Understanding the specific characteristics of Listeria meningitis aids in differential diagnosis and management strategies.
- Further investigation into unusual cases, such as those in older children or with co-infections, is warranted.