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Updated: Dec 25, 2025

Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats
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Systematic scoping review of mandibular bone tissue engineering.

S Basyuni1, A Ferro2, V Santhanam2

  • 1Department of Oral and Maxillo-Facial Surgery, Cambridge University Hospitals, Cambridge, United Kingdom; Department of Surgery, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

The British Journal of Oral & Maxillofacial Surgery
|April 6, 2020
PubMed
Summary

Tissue engineering shows promise for regenerating mandibular bone defects in animal models. Scaffolds like calcium phosphates, combined with mesenchymal stem cells (MSC) and bone morphogenic proteins (BMP), enhance bone formation, but clinical translation requires further research.

Keywords:
bonemandiblereconstructionregenerationtissue engineering

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Oral and Maxillofacial Surgery

Background:

  • Mandibular defects pose significant reconstructive challenges.
  • Tissue engineering offers a potential solution for bony regeneration.
  • Current research focuses on animal models to assess efficacy.

Purpose of the Study:

  • To conduct a scoping systematic review of in vivo research on tissue engineering for mandibular defect reconstruction in animal models.
  • To identify commonly used materials, growth factors, and cell types.
  • To highlight limitations and future directions for clinical translation.

Main Methods:

  • Systematic search of literature databases for relevant studies.
  • Screening of titles, abstracts, and full-text articles.
  • Inclusion of 72 studies involving animal models of mandibular defects.

Main Results:

  • Calcium phosphates (tricalcium phosphate, hydroxyapatite) were the most common scaffolds, promoting bone formation.
  • Mesenchymal stem cells (MSC) combined with scaffolds enhanced new bone formation and healing.
  • Bone morphogenic proteins (BMP) were the most studied growth factors, significantly promoting bone formation.

Conclusions:

  • Tissue engineering strategies, particularly those using scaffolds, MSCs, and BMPs, show significant potential for mandibular bone regeneration.
  • Further understanding of cellular and molecular mechanisms is crucial for optimizing regenerative therapies.
  • Addressing current shortfalls is necessary before widespread clinical translation of these regenerative approaches.