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Related Experiment Videos

TNF: its potential as an antitumour agent.

W Fiers1, R Beyaert, P Brouckaert

  • 1Laboratorium voor Moleculaire Biologie, Rijksuniversiteit Gent, Belgium.

Developments in Biological Standardization
|January 1, 1988
PubMed
Summary

Tumour Necrosis Factor (TNF) can kill cancer cells and induce tumor necrosis, especially with other agents. Reducing TNF

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Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Tumour Necrosis Factor (TNF) was identified for its ability to cause tumor necrosis in vivo.
  • TNF exhibits pleiotropic effects on both normal and transformed cells.
  • Understanding TNF's impact on normal cells, particularly the endothelium, is crucial for assessing its toxicity.

Purpose of the Study:

  • To review the diverse effects of Tumour Necrosis Factor (TNF) on various cell types.
  • To explore the mechanisms underlying TNF's action, including phospholipase-A2 activation and gene induction.
  • To discuss the therapeutic potential and limitations of TNF as an anti-cancer agent.

Main Methods:

  • Literature review of Tumour Necrosis Factor (TNF) research.
  • Analysis of TNF's effects on transformed and normal cells.

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  • Examination of TNF-induced cellular responses, including gene expression and protein synthesis.

    • Main Results:

    • TNF effectively kills many transformed cells, particularly when combined with interferon-gamma or transcription/translation inhibitors.
    • TNF activates phospholipase-A2 and induces genes such as interleukin-6.
    • Interleukin-6, induced by TNF, affects various immune and somatic cells, promoting acute phase protein synthesis.

    Conclusions:

    • TNF demonstrates significant anti-tumour activity in experimental models, capable of complete tumour eradication.
    • TNF's toxicity, especially when combined with interferon, currently limits its clinical application.
    • Strategies to mitigate TNF toxicity, such as indomethacin treatment, may enhance its potential as an anti-cancer therapeutic, alone or in combination therapies.