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Extracellular matrix dynamics in tubulogenesis.

Rajprasad Loganathan1, Charles D Little2, Brenda J Rongish2

  • 1Department of Cell Biology, Johns Hopkins University, Baltimore, MD 21205, USA.

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|April 6, 2020
PubMed
Summary

Biological tubes are essential for life, with their shape and function determined by cells and the extracellular matrix (ECM). This review emphasizes the crucial, yet underappreciated, role of ECM dynamics in tubulogenesis and organ development.

Keywords:
Branching morphogenesisDevelopmentEmbryoExtracellular matrixLumenTubulogenesis

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Histology

Background:

  • Tubular structures are fundamental to metazoan physiology, facilitating vital processes like transport and exchange.
  • The complexity of these biological tubes is closely linked to the properties of their constituent cells and the extracellular matrix (ECM).

Purpose of the Study:

  • To review tubulogenesis, focusing on the dynamic roles of the extracellular matrix (ECM) in shaping biological tubes.
  • To highlight the ECM's morphogenetic influence as a counterpart to cellular dynamics.

Main Methods:

  • Review of existing developmental studies across morphological and molecular levels.
  • Analysis of tubulogenesis in model tubular organs.

Main Results:

  • The extracellular matrix (ECM) is a dynamic, tripartite composite influencing tubulogenesis.
  • ECM dynamics critically determine the shape, size, and function of biological tubes.
  • Evidence from developmental studies supports the ECM's significant role in tubular organ formation.

Conclusions:

  • Cellular and ECM dynamics are key determinants of biological tube development and function.
  • ECM dynamics represent a crucial, under-recognized factor in the morphogenetic processes of tubulogenesis.