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Related Experiment Video

Updated: Dec 25, 2025

Author Spotlight: 3D Scanning and Augmented Reality for Enhanced Cancer Surgery Communication
07:47

Author Spotlight: 3D Scanning and Augmented Reality for Enhanced Cancer Surgery Communication

Published on: December 15, 2023

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Advances in image enhancement for sarcoma surgery.

B C Baljer, S Kolhe, C D Chan

    Cancer Letters
    |April 6, 2020
    PubMed
    Summary

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    Near infra-red fluorescence guided surgery may improve sarcoma resection by clearly defining tumor margins, reducing recurrence and patient morbidity. This technique offers a promising intra-operative tool for complete tumor removal.

    Area of Science:

    • Surgical Oncology
    • Medical Imaging
    • Biotechnology

    Background:

    • Sarcoma recurrence is linked to surgical margin status, necessitating precise tumor removal.
    • Current pre-operative imaging (MRI, radiographs) and intra-operative guidance (fluoroscopy) have limitations in defining margins, leading to overtreatment or incomplete resection.
    • Minimizing surgical morbidity while ensuring adequate tumor-free margins is a critical clinical challenge in sarcoma management.

    Purpose of the Study:

    • To explore the potential of Near Infra-Red (NIR) fluorescence guided surgery as an advanced intra-operative tool for sarcoma resection.
    • To evaluate how NIR imaging can aid surgeons in achieving complete tumor excision with clear margins, thereby reducing morbidity.
    • To assess the preliminary efficacy and potential of NIR fluorescence in improving surgical outcomes for both soft tissue and bone sarcomas.
    Keywords:
    Intra-operative image guidanceNear infra-redPET-CTPET-MRIPre-operative imagingSarcomaTargeted fluorescence

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    Main Methods:

    • Review of current imaging modalities for soft tissue and bone sarcomas, including ultrasound, MRI, radiographs, PET-CT, and PET-MRI.
    • Discussion of the limitations of existing pre-operative and intra-operative techniques in accurately translating imaging data to surgical margins.
    • Introduction of Near Infra-Red (NIR) fluorescence guided surgery as a novel intra-operative approach.

    Main Results:

    • NIR fluorescence guided surgery demonstrates potential for precise tumor margin delineation during operations.
    • Early findings suggest NIR imaging provides valuable intra-operative information on anatomy, perfusion, lymphatic drainage, tumor margins, and metastases.
    • NIR fluorochromes have shown good patient tolerability in preliminary studies.

    Conclusions:

    • NIR fluorescence guided surgery offers a promising adjunct to sarcoma surgery, potentially enabling complete tumor resection with adequate margins and reduced morbidity.
    • Further research on cost-effectiveness and protocol development is essential before widespread clinical implementation.
    • NIR imaging holds the potential to significantly transform the surgical management of sarcomas in the future.