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Factors associated with early phosphate levels in preterm infants
Daniel Yakubovich1,2, Tzipi Strauss2,3, Dror Ohana2
1Department of Pediatrics, Schneider Children's Medical Center, Petah Tikva, Israel.
European Journal of Pediatrics
|April 6, 2020
Summary
Early enteral nutrition in preterm infants is linked to higher serum phosphate (sPhos) levels. However, sPhos was not associated with adverse neonatal outcomes in this study.
Area of Science:
- Neonatalogy
- Pediatric Nutrition
- Biochemistry
Background:
- Hypophosphatemia is a concern in preterm infants, potentially linked to nutrition.
- Understanding factors influencing early serum phosphate (sPhos) is crucial for preterm infant care.
Purpose of the Study:
- To examine perinatal factors and early morbidities related to early serum phosphate (sPhos) in preterm infants.
- To identify predictors of sPhos levels and potential associations with neonatal outcomes.
Main Methods:
- Retrospective analysis of 454 preterm infants (<32 weeks gestational age).
- Data collection included perinatal factors, nutrition, and early morbidities.
- Statistical analysis to determine associations with early sPhos levels.
Main Results:
- Early sPhos levels positively correlated with gestational age, weight z-score, and Apgar scores.
- Higher sPhos was associated with earlier enteral nutrition initiation and breast milk-rich diets.
- Maternal hypertension, lactate, hypotension, and protein supplementation were inversely associated with sPhos.
Conclusions:
- Early enteral nutrition within 72 hours is associated with higher sPhos in preterm infants.
- sPhos levels are linked to nutritional timing/content and neonatal hemodynamics.
- No significant early morbidities were identified as being associated with sPhos after adjustments.
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