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Related Concept Videos

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Nursing diagnoses represent a problem validated by major defining characteristics. There are four categories of nursing diagnoses: problem-focused, risk, health promotion or wellness, and syndrome. The anatomy of a nursing diagnosis includes three components: problem statement or diagnostic label, defining characteristics, and related factors.
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The goodness–of–fit test can be used to decide whether a population fits a given distribution, but it will not suffice to decide whether two populations follow the same unknown distribution. A different test, called the test for homogeneity, can be used to conclude whether two populations have the same distribution. To calculate the test statistic for a test for homogeneity, follow the same procedure as with the test of independence. The hypotheses for the test for homogeneity can...
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The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
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The nurse documents nursing diagnoses and enters them into the patient record. The identified patient's nursing diagnosis is either written out with a plan of care or entered into the electronic health record.
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Related Experiment Video

Updated: Dec 25, 2025

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
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Dent disease: classification, heterogeneity and diagnosis.

Yan-Yan Jin1, Li-Min Huang1, Xiao-Fang Quan2

  • 1Department of Nephrology, National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, #57 Zhugan Lane, Hangzhou, 310006, China.

World Journal of Pediatrics : WJP
|April 6, 2020
PubMed
Summary

Dent disease is a rare genetic kidney tubulopathy affecting males, with known causes for most cases. Further research is needed to identify the genetic basis of remaining Dent disease cases.

Keywords:
CLCN5 geneDent diseaseOCRL gene

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Area of Science:

  • Nephrology
  • Genetics
  • Pediatrics

Background:

  • Dent disease is a rare X-linked tubulopathy causing proximal tubular dysfunction, primarily in males.
  • Symptoms manifest in early childhood, potentially progressing to end-stage renal failure.
  • Two forms, Dent disease 1 and 2, are linked to CLCN5 and OCRL gene mutations, respectively, accounting for 75% of cases.

Purpose of the Study:

  • To review current research progress in the classification, genetic heterogeneity, diagnosis, and treatment of Dent disease.
  • To provide a comprehensive understanding for clinicians and researchers.
  • To establish a foundation for improved prevention and treatment strategies.

Main Methods:

  • Comprehensive literature search of peer-reviewed original articles from PubMed.
  • Screening and referencing of all relevant published studies.

Main Results:

  • Genetic testing, including next-generation sequencing, has identified CLCN5 and OCRL mutations.
  • The genetic cause for 25% of Dent disease cases remains unidentified.
  • Gene therapy shows promise for Dent disease treatment; avoidance of hormone and immunosuppressive agent abuse is crucial.

Conclusions:

  • Understanding the classification, genetic basis, and diagnostic approaches is vital for managing Dent disease.
  • Continued research into the genetic heterogeneity of Dent disease is necessary.
  • Improved diagnostic and therapeutic strategies are emerging, emphasizing the need for cautious treatment approaches.