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Enzymes for pharmaceutical and therapeutic applications
Gautam Kumar Meghwanshi1, Navpreet Kaur1, Swati Verma1
1Department of Microbiology, M.G.S. University, Bikaner, India.
Biotechnology and Applied Biochemistry
|April 6, 2020
Summary
Enzymes are efficient biocatalysts offering advantages over chemical catalysts in pharmaceutical synthesis. This review covers enzyme production and their diverse applications in drug development and therapies.
Area of Science:
- Biochemistry and Organic Chemistry
- Enzymology and Biocatalysis
Background:
- Enzymes are nature's highly efficient and selective biocatalysts, catalyzing a wide array of reactions.
- Enzymatic catalysis offers superior fidelity and milder conditions compared to traditional chemical methods.
Purpose of the Study:
- To provide an overview of enzyme production and their applications in pharmaceutical synthesis.
- To highlight the advantages of using enzymes in various chemical transformations relevant to drug development.
Main Methods:
- Review of literature on enzyme production and applications.
- Compilation of reaction schemes and examples of enzyme-catalyzed pharmaceutical transformations.
- Inclusion of diagrams and tables for clarity.
Main Results:
- Enzymes catalyze diverse reactions including oxidation-reduction, hydrolysis, and bond formation/cleavage with high selectivity.
- Enzymatic processes are crucial for pharmaceutical applications like selective protection/deprotection, deracemization, and kinetic resolution.
- Enzymes offer an efficient and environmentally friendly alternative to chemical catalysts in drug synthesis.
Conclusions:
- Enzymes are invaluable tools in pharmaceutical industries due to their efficiency, selectivity, and mild reaction conditions.
- Enzyme-based therapies and synthetic applications represent a significant advancement in modern medicine and drug discovery.
- Further exploration of enzyme production and application will continue to drive innovation in pharmaceuticals.
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