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Incidence and risk factors for stroke following percutaneous coronary intervention
Luke P Dawson1,2, Justin A Cole1,3, Terase F Lancefield4
1Department of Cardiovascular Medicine, The Alfred Hospital, Melbourne, Australia.
Insights
Stroke incidence after percutaneous coronary intervention (PCI) varies by patient age. Younger patients (<65) have higher outpatient stroke rates post-PCI compared to the general population, while older patients (≥65) have lower rates.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Public Health
Background:
- Percutaneous coronary intervention (PCI) practices are evolving, necessitating updated data on stroke incidence.
- There is a lack of comparative data on stroke rates following PCI versus the general population.
Purpose of the Study:
- To determine the incidence and risk factors for inpatient and subsequent outpatient stroke after PCI.
- To compare stroke rates in PCI patients with age-matched controls from the general population.
Main Methods:
- Prospective data collection from 22,618 patients undergoing PCI (2005-2015).
- Comparison with the North-East Melbourne Stroke Incidence Study population-based cohort (1997-1999).
- Assessment of variables associated with inpatient or outpatient stroke.
Main Results:
- Inpatient stroke occurred in 0.33% and outpatient stroke in 0.55% of PCI patients.
- Inpatient and outpatient strokes were linked to increased in-hospital and 12-month mortality.
- Independent risk factors for inpatient stroke included renal impairment and female sex; for outpatient stroke, they included previous stroke and older age.
Conclusions:
- Inpatient stroke risk is tied to clinical status at presentation; outpatient stroke risk is linked to age and chronic disease.
- Outpatient stroke rates post-PCI are higher in younger patients (<65) but lower in older patients (≥65) compared to the general population.
Background:
Stroke rates and risk factors may change as percutaneous coronary intervention practice evolves and no data are available comparing stroke incidence after percutaneous coronary intervention to the general population.
Aims:
This study aimed to identify the incidence and risk factors for inpatient and subsequent stroke following percutaneous coronary intervention with comparison to age-matched controls.
Methods:
Data were prospectively collected from 22,618 patients undergoing percutaneous coronary intervention in the Melbourne Interventional Group registry (2005-2015). The cohort was compared to the North-East Melbourne Stroke Incidence Study population-based cohort (1997-1999) and predefined variables assessed for association with inpatient or outpatient stroke.
Results:
Inpatient stroke occurred in 0.33% (65.3% ischemic, 28.0% haemorrhagic, and 6.7% cause unknown), while outpatient stroke occurred in 0.55%. Inpatient and outpatient stroke were associated with higher rates of in-hospital major adverse cardiovascular outcomes (p < 0.0001) and mortality (p < 0.0001), as well as 12-month mortality (p < 0.0001). Factors independently associated with inpatient stroke were renal impairment, ST-elevation myocardial infarction, previous stroke, left ventricular ejection fraction 30-45%, and female sex, while those associated with outpatient stroke were previous stroke, chronic lung disease, previous myocardial infarction, rheumatoid arthritis, female sex, and older age. Compared to the age-standardized population-based cohort, stroke rates in the 12 months following discharge were higher for percutaneous coronary intervention patients <65 years old, but lower for percutaneous coronary intervention patients ≥65 years old.
Conclusions:
Risk of inpatient stroke following percutaneous coronary intervention appears to be largely associated with clinical status at presentation, while outpatient stroke relates more to age and chronic disease. Compared to the general population, outpatient stroke rates following percutaneous coronary intervention are higher for younger, but not older, patients.
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