Hemodynamic gain index in women: A validation study.

Area of Science:

• Cardiology
• Preventive Medicine
• Exercise Physiology

Background:

• Previous research established a strong association between hemodynamic gain index (HGI) and all-cause mortality in men.
• The current study aimed to validate this association in a female cohort.

Purpose of the Study:

• To validate the prognostic value of the hemodynamic gain index (HGI) for all-cause mortality in women.
• To assess the association between HGI and mortality risk in a pilot cohort of women.

Main Methods:

• Prospective follow-up of 606 women (mean age 54.1 years) for 8.0 years.
• Hemodynamic gain index (HGI) calculated using [(HRpeak*SBPpeak)-(HRrest*SBPrest)]/(HRrest*SBPrest) from treadmill exercise testing.
• Bivariable and multivariable Cox hazard models analyzed for HGI and all-cause mortality.

Main Results:

• 48 participants (7.9%) died during follow-up.
• Higher HGI was significantly associated with reduced all-cause mortality risk in both bivariable (HR 0.36) and multivariable (HR 0.55) analyses.
• Participants in higher HGI percentile groups showed substantial reductions in mortality risk (up to 90%).

Conclusions:

• This study validates that a higher hemodynamic gain index (HGI) is associated with a lower risk of all-cause mortality in women.
• HGI demonstrates prognostic value for risk stratification in both clinical and research settings.
• The findings support the use of HGI in assessing cardiovascular health and mortality risk in women.