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Frédéric Bibeau1, Alexandre Léger1, Céline Bazille1

  • 1Service d'anatomie pathologique, université de Caen, CHU de Caen, avenue côte de Nacre, 14053 Caen cedex, Normandie.

Annales De Pathologie
|April 7, 2020
PubMed
Summary
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Pathologists play a key role in identifying hereditary colorectal cancer by recognizing specific patterns. Their findings guide oncogenetic consultations and germline mutation research for accurate diagnosis and management.

Area of Science:

  • Pathology
  • Oncology
  • Genetics

Background:

  • Hereditary colorectal cancer (HCC) accounts for a significant proportion of all colorectal cancers.
  • Early and accurate diagnosis of HCC is crucial for effective patient management and family screening.
  • The pathologist's expertise is vital in suspecting and diagnosing hereditary cancer syndromes.

Purpose of the Study:

  • To outline the essential aspects of hereditary colorectal cancers relevant to pathologists.
  • To highlight key histopathological features of different hereditary colorectal cancer entities.
  • To define the pathologist's role within the multidisciplinary management of these cancers.

Main Methods:

  • Review of histopathological features of common hereditary colorectal cancer syndromes.
Keywords:
Cancer colique héréditaireHereditary colon cancerMSIPathologistPathologistePolyposesPolyposis

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  • Integration of morphological findings with clinical and genetic information.
  • Discussion of the pathologist's contribution to diagnostic pathways.

    • Main Results:

    • Specific histopathological criteria can suggest a hereditary basis for colorectal cancer.
    • Pathologists' observations are critical for initiating further genetic testing and counseling.
    • Accurate pathological assessment aids in differentiating hereditary from sporadic colorectal cancers.

    Conclusions:

    • The pathologist is instrumental in the initial detection and characterization of hereditary colorectal cancer.
    • Close collaboration between pathologists, clinicians, and geneticists is essential for optimal patient care.
    • Histopathological analysis provides a foundation for oncogenetic consultation and germline mutation research in suspected hereditary cases.