Exploring the photo protective potential of solid lipid nanoparticle-based sunscreen cream containing Aloe vera

Nowadays, the sunscreen creams are composed of mostly synthetic chemicals and other organic compounds which were found to enter into the blood stream on topical application raising concerns in the scientific community. The scientific community has now shifted their attention to herbal formulations due to toxicity of these synthetic molecules. Aloe vera is a xerophitic plant having excellent anti-oxidant properties. The permeation effect and drug stability of the drug candidate can be significantly enhanced by formulating it into solid lipid nanoparticles (SLN). The main objectives of the study were to formulate and evaluate Aloe vera-loaded SLN sunscreen cream and to determine its photoprotective potential. The Aloe vera-loaded SLNs were formulated by microemulsification technique. The developed SLNs were studied for its entrapment efficiency, poly dispersity index (PDI), zeta potential, particle size, and other characterization techniques. Finally, the optimized SLNs were incorporated into the sunscreen cream and evaluated for its spreadability, viscosity, extrudability, drug content, in vitro drug release, ex vivo permeation, determination of sun protection factor (SPF), skin irritation test, and accelerated stability studies. The in vitro SPF was found out to be 16.9 ± 2.44 and the in vivo SPF observed to be approximately 14.81 ± 3.81, respectively. Stability studies were performed under accelerated conditions and no appreciable changes in the parameters were noticed. The solid lipid nanoparticles of Aloe vera were incorporated into a cream and the SPF of the resultant sunscreen cream was found to be on par with the sunscreens that were currently available in the market.