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Updated: Dec 25, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
Published on: December 1, 2023
The role of B cells in the immunopathogenesis of multiple sclerosis
Tohid Gharibi1,2,3,4,5, Zohreh Babaloo1,2, Arezoo Hosseini1,2,3,4
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis (MS). The success of B-cell targeting therapies in MS highlighted the role of B cells, particularly the antibody-independent functions of these cells such as antigen presentation to T cells and modulation of the function of T cells and myeloid cells by secreting pathogenic and/or protective cytokines in the central nervous system. Here, we discuss the role of different antibody-dependent and antibody-independent functions of B cells in MS disease activity and progression proposing new therapeutic strategies for the optimization of B-cell targeting treatments.
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