Intensity-modulated radiation therapy for multiple targets with tomotherapy using multiple sets of static ports from...

Area of Science:

• Radiation Oncology
• Medical Physics
• Cancer Treatment

Background:

• A new pseudo-dynamic jaw displacement (pDJDC) technique was developed for rapid treatment of multiple, spatially separated targets using static-port tomotherapy.
• This technique was compared against helical tomotherapy using the dynamic-jaw mode (HDJ) for treating multiple targets.

Purpose of the Study:

• To evaluate the efficacy and safety of the pDJDC technique compared to the HDJ technique for treating multiple targets.
• To assess treatment time, dose distribution, conformity, and uniformity.

Main Methods:

• Seven patients with multiple targets were treated with both pDJDC and HDJ techniques.
• Plans were compared based on conformity index, uniformity index (D5%/D95%), lung dose distribution (mean lung dose, V5Gy, V20Gy), and treatment duration.

Main Results:

• The pDJDC technique reduced treatment time by 48% (median 462s vs. 884s, P=0.031).
• Conformity index was slightly worse for pDJDC (3.0 vs. 2.4, P=0.031), but uniformity index was comparable (1.048 vs. 1.057, P=0.10).
• Lung dose parameters were similar between the two techniques.

Conclusions:

• The pDJDC technique offers a significant reduction in treatment time for multiple targets.
• While dose distribution is comparable, the pDJDC technique results in a slightly lower conformity index.
• pDJDC is a promising technique for efficient multi-target radiotherapy.