An Operationally Simple and Efficient Synthesis of 7-Benzylidene-substitutedphenyl-
Santosh Raut1, Bharat Dhotre2, Atul Tidke1
1Department of Chemistry, Maulana Azad College, Aurangabad, India.
Background:
An eco-friendly, operationally simple and efficient reaction is shown between various 2,6-bis-(substituted-benzylidene)-cyclohexanones and differently substituted hydrazine in the presence of acetic acid.
Methods:
The reaction between various 2,6-bis-(substituted-benzylidene)-cyclohexanones and differently substituted hydrazine in the presence of acetic acid afforded 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7- hexahydro-2H-indazole in 74 to 92 % yield in short reaction time using the grindstone technique.
Results And Discussion:
The notable advantages of this method include mild synthetic conditions, weak acid catalysis, and non-hazardous solvent which make this method environmentally safer.
Conclusion:
In conclusion, we have developed an efficient, simple and eco-friendly method for the synthesis of 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-hexahydro-2H-indazole by grinding technique. The notable benefits of this method are waste minimization, no organic solvent required, simple procedure, easy work-up, and clean reaction profile.
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