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Immunologic surface markers in non-Hodgkin's lymphomas.

J Cossman, B Schnitzer, M J Deegan

The American Journal of Pathology

|April 1, 1977

Summary

Immunologic cell surface markers were analyzed in non-Hodgkin's lymphomas. Complement receptor (CR) B lymphocytes were prevalent in most examined lymphoma subtypes, aiding in their characterization.

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Area of Science:

Immunology
Oncology
Pathology

Background:

Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoid malignancies.
Accurate subtyping of NHL is crucial for prognosis and treatment.
Immunologic cell surface markers can aid in classifying lymphoid neoplasms.

Purpose of the Study:

To investigate the distribution patterns of complement receptor (CR) B lymphocytes and Fc receptor (FcR)-bearing histiocytes in various subtypes of non-Hodgkin's lymphomas.
To compare these immunologic markers in tumor tissue with routine histology and normal lymphoid tissue.

Main Methods:

Analysis of tissue samples from 21 patients diagnosed with non-Hodgkin's lymphomas.
Evaluation of immunologic cell surface markers, specifically complement receptors (CR) and Fc receptors (FcR).
Comparison of marker distribution in tumor tissue, routine histologic preparations, and normal tissue.

Main Results:

Dense populations of CR B lymphocytes were found in all 6 cases of nodular, poorly differentiated lymphocytic lymphoma (NPDLL).
CR B lymphocytes predominated in involved tissue from 7 of 8 patients with diffuse, poorly differentiated lymphocytic lymphoma (DPDLL).
Fc receptors were identified on cells in 1 of 3 histiocytic lymphoma cases, and CR B cells were noted in a cell suspension from an undifferentiated lymphoma.

Conclusions:

Complement receptor B lymphocytes are a significant component in several subtypes of non-Hodgkin's lymphomas, including NPDLL and DPDLL.
Immunohistochemical analysis of cell surface markers provides valuable insights into the cellular composition of lymphoma infiltrates.
Further characterization of immunologic markers may refine diagnostic and prognostic assessments in non-Hodgkin's lymphomas.

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