Importance of intensive blood pressure control in type 2 diabetes: Mechanisms, treatments and current guidelines

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Michel Marre1,2,3

  • 1INSERM U1138, Centre de Recherches des Cordeliers, Paris, France.

Diabetes, Obesity & Metabolism
|April 7, 2020
PubMed

Insights

Intensified blood pressure reduction benefits people with diabetes. Renin-angiotensin-aldosterone system (RAAS) blockers are recommended, supporting updated guidelines for blood pressure targets in diabetic patients.

Area of Science:

  • Cardiology
  • Diabetology
  • Pharmacology

Background:

  • Intensified blood pressure (BP) reduction offers benefits for individuals with diabetes.
  • Renin-angiotensin-aldosterone system (RAAS) blockers are favored due to their unique hemodynamic properties.

Purpose of the Study:

  • To evaluate the impact of intensified BP reduction in people with diabetes.
  • To assess the alignment of findings with current European treatment guidelines.

Main Methods:

  • Analysis of observational and interventional studies.
  • Focus on the blood pressure arm of the ADVANCE study.

Main Results:

  • Strong support for intensified BP reduction in diabetic populations.
  • Evidence aligns with updated European Society of Cardiology/European Association of Diabetes recommendations.

Conclusions:

  • Recommended BP target for people with diabetes is 130/80 mmHg.
  • Fixed-dose combinations of RAAS blockers with diuretics or calcium channel blockers are suggested as first-line therapy.

Keywords:
diabetes complicationstype 2 diabetes

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