Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

277
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
277

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue clearing and light-sheet fluorescence microscopy for three-dimensional mapping of placental vascularization.

Placenta·2026
Same author

Image-informed modelling of microscale exchange in the human placenta.

Placenta·2026
Same author

Andrée Gruslin award lecture: Vitamin D, pregnancy and the human placenta.

Placenta·2026
Same author

Physiological and anatomical determinants of placental drug transfer.

The Journal of physiology·2026
Same author

From mice to rhinos: Whole-organ quantification of 3D mammalian placental structure using correlative multiscale imaging.

Placenta·2026
Same author

Placental crises: disruptive selection and maternal under-investment as the foundations of mammalian placental evolution and dysfunction.

Biological reviews of the Cambridge Philosophical Society·2026

Related Experiment Video

Updated: Dec 24, 2025

Ex Vivo Perfusion of the Rodent Placenta
06:54

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

10.3K

Placental perfusion and mathematical modelling.

Rohan M Lewis1, Jane K Cleal1, Bram G Sengers2

  • 1University of Southampton, Faulty of Medicine, UK; University of Southampton, Institute for Life Sciences, UK.

Placenta
|April 7, 2020
PubMed
Summary
This summary is machine-generated.

Combining placental perfusion with mathematical modeling offers new insights into placental function. This integrated approach helps identify key factors in placental dysfunction and pathology.

Keywords:
Computational modellingPlacental transfer

More Related Videos

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
08:08

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

17.8K
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

11.0K

Related Experiment Videos

Last Updated: Dec 24, 2025

Ex Vivo Perfusion of the Rodent Placenta
06:54

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

10.3K
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
08:08

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

17.8K
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

11.0K

Area of Science:

  • Physiology
  • Biochemistry
  • Computational Biology

Background:

  • The isolated perfused placental cotyledon technique has advanced placental biology.
  • Mathematical modeling offers a quantitative framework to understand complex placental functions.

Purpose of the Study:

  • To integrate placental perfusion data with mathematical modeling for a deeper understanding of placental physiology.
  • To quantitatively assess the contribution of different processes to overall placental function.
  • To identify rate-limiting factors in placental transport and metabolism.

Main Methods:

  • Utilizing the isolated perfused placental cotyledon technique.
  • Applying mathematical modeling to perfusion data.
  • Controlling experimental conditions and measuring functional parameters (pressure, solute concentration, pH).

Main Results:

  • Placental metabolism significantly influences amino acid and fatty acid transfer.
  • Metabolism plays a less critical role in placental cortisol transfer than previously assumed.
  • Quantitative analysis identified relative contributions of transport, metabolism, and blood flow.

Conclusions:

  • An integrated experimental and modeling approach provides a comprehensive view of placental physiology.
  • Identifying rate-limiting factors is crucial for understanding and addressing placental dysfunction.
  • This combined approach can more effectively pinpoint processes leading to placental pathologies.