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Schistosome TRP channels: An appraisal
Swarna Bais1, Robert M Greenberg1
1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA, 19104, USA.
Summary
Transient receptor potential (TRP) channels in schistosomes are key targets for anthelmintic drugs. Recent studies reveal unusual properties and praziquantel activation, offering new therapeutic strategies.
Area of Science:
- Molecular Biology
- Parasitology
- Pharmacology
Background:
- Ion channels are crucial for cellular functions and are targets for anthelmintic drugs.
- Transient receptor potential (TRP) channels are a diverse superfamily involved in sensory signaling and ion homeostasis.
- TRP channels in parasitic helminths, particularly schistosomes, have been under-investigated until recently.
Purpose of the Study:
- To update and reassess the TRP channel repertoire in Schistosoma mansoni.
- To examine recent findings on schistosome TRP channels as potential therapeutic targets.
- To explore the physiological functions mediated by these channels in schistosomes.
Main Methods:
- Bioinformatic analysis of the Schistosoma mansoni genome database.
- Review of recent experimental findings on schistosome TRP channel properties.
- Comparative analysis of TRP channel sequences and structures.
Main Results:
- The Schistosoma mansoni genome database reveals significant changes in predicted TRP channel sequences.
- Some schistosome TRP channels exhibit unique pharmacological properties.
- Both mammalian and schistosome TRP channels are activated by praziquantel, the primary antischistosomal drug.
Conclusions:
- Schistosome TRP channels represent promising targets for novel anthelmintic drug development.
- Understanding the specific functions of these TRP channels can guide future therapeutic interventions.
- Further research into schistosome TRP channel pharmacology and physiology is warranted.
