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Testing the endometrium: is there enough evidence to justify clinical use?
1London Women's Clinic, London, UK.
Current Opinion in Obstetrics & Gynecology
|April 7, 2020
Summary
New endometrial biomarkers can improve assisted reproduction success by assessing embryo-endometrial synchrony and immune activation. These markers offer targeted therapies for implantation failure, moving beyond empirical treatments.
Area of Science:
- Reproductive Medicine
- Biomarker Discovery
- Assisted Reproduction Technologies
Background:
- Embryo implantation is a key limitation in assisted reproduction.
- Current research primarily focuses on embryo quality and selection.
- Plateauing success rates necessitate exploring endometrial factors.
Purpose of the Study:
- To review evidence on novel endometrial biomarkers for assisted reproduction.
- To focus on biomarkers assessing embryo-endometrial synchrony and immune activation.
- To discuss emerging biomarkers including microbiome, noncoding RNAs, microvesicles, and glycans.
Main Methods:
- Review of recent scientific literature on endometrial biomarkers.
- Emphasis on biomarkers related to developmental synchrony and immune modulation.
- Inclusion of emerging areas like reproductive tract microbiome and materno-fetal dialogue markers.
Main Results:
- Several biomarkers show potential clinical value in assessing endometrial function.
- Biomarkers can evaluate embryo-endometrial synchrony and endometrial immune activation.
- Emerging markers include noncoding RNAs, microvesicles, and endometrial glycans.
Conclusions:
- Innovative endometrial biomarkers offer potential for targeted therapies against implantation failure.
- These biomarkers can guide personalized treatments and clinical trials.
- Further validation studies are required for widespread clinical application.
