A novel endoscopic visible full-thickness cryoablation device on stomach

Area of Science:

• Gastroenterology
• Surgical Oncology
• Medical Devices

Background:

• Cryoablation is used for visceral tumors, but endoscopic gastric cryoablation lacks precise control.
• Accurate control of ablation site, freezing depth, and temperature are critical for gastric tumor treatment.

Purpose of the Study:

• To develop and evaluate a novel endoscopic device for accurate cryoablation of gastric tumors.
• To assess the efficacy and safety of this device in a porcine stomach model.

Main Methods:

• Development of a novel endoscopic cryoablation device with direct visualization.
• Application of the device for 3-minute cryoablation on a porcine stomach.
• Evaluation of lesion characteristics, temperature changes, histopathology, and long-term recovery.

Main Results:

• The device enabled accurate and safe endoscopic gastric ablation.
• A 3-minute cryoablation resulted in a transmural gastric lesion (1 cm radius).
• Histopathology showed cell damage and tissue disruption, with complete structural recovery and scarring after 3 months, with no adverse events.

Conclusions:

• The novel endoscopic cryoablation device provides safe, full-thickness ablation with effective temperature control.
• This technology presents a potential alternative treatment modality for gastric tumors.