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Updated: Dec 24, 2025

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

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Identification of a novel fusion gene, TRIM52-RACK1, in oral squamous cell carcinoma

Tao Pan1, Yong-Guo Li2, Ke-Yi Li2

  • 1Key Lab of Precision Biomedicine & Department of Stomatology, Liaocheng People's Hospital, College of Stomatology, Shandong First Medical University, China.

Molecular and Cellular Probes
|April 7, 2020
PubMed

Insights

Researchers identified 11 novel gene fusions in oral squamous cell carcinoma (OSCC). The TRIM52-RACK1 fusion promotes OSCC progression, suggesting it as a potential therapeutic target for this cancer.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Gene fusions are increasingly recognized in cancer development and progression.
  • Novel fusion genes are potential therapeutic targets.
  • The role of gene fusions in oral squamous cell carcinoma (OSCC) progression is understudied.

Purpose of the Study:

  • To identify novel gene fusions in oral squamous cell carcinoma (OSCC) cells.
  • To investigate the functional role of the TRIM52-RACK1 fusion gene in OSCC progression.
  • To evaluate TRIM52-RACK1 as a potential therapeutic target for OSCC.

Main Methods:

  • Identification of gene fusions in OSCC cells using molecular techniques.
  • Analysis of the genomic structure of the TRIM52-RACK1 fusion.
  • In vitro functional assays to assess the impact of TRIM52-RACK1 on OSCC cell proliferation, migration, and invasion.

Main Results:

  • Eleven fused genes were identified in OSCC cells.
  • The TRIM52-RACK1 fusion gene results from a deletion at chromosomal location 5q35.3.
  • TRIM52-RACK1 significantly promoted OSCC cell proliferation, migration, and invasion in vitro.

Conclusions:

  • TRIM52-RACK1 is a novel oncogenic fusion gene in oral squamous cell carcinoma (OSCC).
  • TRIM52-RACK1 plays a crucial role in promoting OSCC progression.
  • TRIM52-RACK1 represents a promising therapeutic target for OSCC treatment.
Keywords:
Fused geneOral squamous cell carcinomaRACK1TRIM52TRIM52-RACK1

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