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The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and
Spyridon G Deftereos1, Gerasimos Siasos1, Georgios Giannopoulos2
1Medical School, National & Kapodistrian University of Athens, Athens, Greece.
Objective:
Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention.
Methods:
Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group.
Results:
Trial results will be disseminated through peer-reviewed publications and conference presentations.
Conclusion:
GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790).
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