Related Experiment Video
Updated: Dec 24, 2025

Fluorescence Time-lapse Imaging of the Complete S. venezuelae Life Cycle Using a Microfluidic Device
Published on: February 28, 2016
Structurally diverse vibralactones produced by the fungus Stereum hirsutum
Yu Liang1, Qin Li1, Mengsha Wei1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Abstract:
Eight unexpected vibralactone homodimers, bisvibralactones A-H (1-8), and three new vibralactone monomers, hirsutumins A-C (9-11), were isolated from the culture of Stereum hirsutum. Their structures and absolute configurations were determined by detailed analyses of NMR, optical rotations, ECD, and high-resolution mass spectra as well as chemical transformation. Compounds 1-8 are unusual vibralactone dimers formed by the esterification of two vibralactone monomers. The absolute configurations of compounds 1 and 5 were determined by chemical conversions. All of the isolated compounds were evaluated for Porcine Pancreatic Lipase (PPL) inhibitory activities, and compound 10 showed significant inhibitory activity against PPL, with an IC50 value of 8.31 ± 1.04 μM.
Related Concept Videos
Fungal Group Zygomycota
Fungal Phylum Ascomycota
Fungal Phylum Basidiomycota
Bacterial Phylum Actinobacteria
Fungal Phylum Microsporidia
Overview of Fungi

