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Modeling Chemotherapy Resistant Leukemia In Vitro
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Bone morbidity in pediatric acute lymphoblastic leukemia.

Moon Bae Ahn1, Byung-Kyu Suh1

  • 1Department of Pediatrics, College of Medicine, Catholic University of Korea, Seoul, Korea.

Annals of Pediatric Endocrinology & Metabolism
|April 8, 2020
PubMed
Summary

Pediatric leukemia survivors face significant bone health issues due to treatment and disease. This review highlights skeletal morbidity and effective strategies to prevent bone loss and fractures in these children.

Keywords:
Bone mineral densityOsteoporosisVertebral fractureAcute lymphoblastic leukemia

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Area of Science:

  • Pediatric Hematology-Oncology
  • Endocrinology
  • Bone Metabolism

Background:

  • Acute lymphoblastic leukemia (ALL) is the most common childhood cancer with high cure rates.
  • Children with ALL experience high rates of endocrine disorders and skeletal morbidity.
  • Leukemia and its treatments, particularly glucocorticoids, impair bone formation and increase destruction.

Purpose of the Study:

  • To review bone morbidity in pediatric patients treated for ALL.
  • To increase awareness of skeletal outcomes among pediatric specialists.
  • To provide an overview of bone pathology in ALL survivors.

Main Methods:

  • Literature review focusing on skeletal outcomes in pediatric ALL.
  • Analysis of factors contributing to bone demineralization and osteoclastogenesis.
  • Discussion of diagnostic methods like Dual-energy X-ray absorptiometry (DXA).

Main Results:

  • ALL survivors are at risk for decreased bone formation and osteoporosis.
  • Glucocorticoids significantly impact bone mineral density and osteoclast activity.
  • Hormone deficiencies post-treatment further affect bone mineral accrual.

Conclusions:

  • Bone morbidity is a critical concern for pediatric ALL survivors.
  • Early detection and intervention are crucial for managing skeletal complications.
  • Strategies include calcium/vitamin D supplementation, bisphosphonates, and exercise.