Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypothesis: Nutrient Off-Loading and Ectopic Fat Reduction Reverse Insulin Resistance and Improve Cardiovascular Outcomes in Type 2 Diabetes-A Narrative Review.

International journal of molecular sciences·2026
Same author

The Pivotal Role of the Western Diet, Hyperinsulinemia, Ectopic Fat, and Diacylglycerol-Mediated Insulin Resistance in Type 2 Diabetes.

International journal of molecular sciences·2025
Same author

G Protein-coupled and Membrane Tyrosine Kinase Receptor Relationships Yield Therapeutic Opportunities.

Endocrine reviews·2025
Same author

The Causal Role of Ectopic Fat Deposition in the Pathogenesis of Metabolic Syndrome.

International journal of molecular sciences·2025
Same author

Overnutrition, Hyperinsulinemia and Ectopic Fat: It Is Time for A Paradigm Shift in the Management of Type 2 Diabetes.

International journal of molecular sciences·2024
Same author

The Impact of Westernization on the Insulin/IGF-I Signaling Pathway and the Metabolic Syndrome: It Is Time for Change.

International journal of molecular sciences·2023

Related Experiment Video

Updated: Dec 24, 2025

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.1K

New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations.

Joseph A M J L Janssen1

  • 1Department of Internal Medicine, Erasmus MC, Room Rg 527 Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Cells
|April 8, 2020
PubMed
Summary

Insulin-like growth factor-I receptor (IGF-IR) signaling is more complex than previously understood, involving kinase-independent functions and cross-talk with other receptors. Translating these complex IGF-IR pathways into clinical practice is crucial for disease diagnosis and treatment.

Keywords:
G-proteinsGPCRsIGF-IIGF-IIIGF-IRIRsfunctional RTK/GPCR hybridhybridsinsulinnuclear translocationphosphorylationtyrosine kinase receptorβ-arrestins

More Related Videos

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
08:34

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay

Published on: July 15, 2025

546
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

746

Related Experiment Videos

Last Updated: Dec 24, 2025

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.1K
Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
08:34

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay

Published on: July 15, 2025

546
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

746

Area of Science:

  • Cellular biology
  • Molecular signaling
  • Cancer research

Background:

  • Insulin-like growth factors (IGFs) are critical for cell growth, differentiation, and survival.
  • The Insulin-like Growth Factor-I Receptor (IGF-IR) is central to IGF signaling and implicated in cancer.
  • Previous understanding viewed IGF-IR solely as a tyrosine kinase receptor.

Purpose of the Study:

  • To explore the multifaceted nature of IGF-IR signaling pathways.
  • To highlight recent discoveries expanding the functional repertoire of IGF-IR.
  • To address the challenge of translating complex IGF-IR knowledge into clinical applications.

Main Methods:

  • Review of current scientific literature on IGF-IR signaling.
  • Analysis of emerging evidence on IGF-IR's non-canonical functions.
  • Examination of cross-talk mechanisms between IGF-IR and other receptor systems.

Main Results:

  • IGF-IR exhibits kinase-independent functions and signals in an unoccupied state.
  • IGF-IR forms hybrid receptors with insulin receptors and other receptor tyrosine kinases (RTKs).
  • IGF-IR engages with G-protein coupled receptor (GPCR) pathways, acting as a functional RTK/GPCR hybrid.
  • IGF-IR can translocate to the nucleus, functioning as a transcriptional cofactor.

Conclusions:

  • IGF-IR signaling is far more complex than the traditional tyrosine kinase model.
  • The receptor integrates diverse signaling pathways, including kinase-dependent, kinase-independent, and GPCR-like mechanisms.
  • Future efforts must focus on translating these complex IGF-IR signaling insights into improved clinical diagnostics and therapeutics.