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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

294
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
294
Overview of the Heart01:07

Overview of the Heart

12.2K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
12.2K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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COVID-19 and the Heart.

Akbarshakh Akhmerov1, Eduardo Marbán1

  • 1From the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.

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|April 8, 2020
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This summary is machine-generated.

Severe COVID-19 causes systemic illness with hyperinflammation and cardiac injury. This review covers COVID-19 pathophysiology, cardiovascular effects, and potential treatments as of April 2020.

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathophysiology

Background:

  • Severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) causes COVID-19.
  • Severe COVID-19 presents as a systemic illness with hyperinflammation and cytokine storm.
  • Cardiac injury biomarkers are often elevated in severe COVID-19 cases.

Purpose of the Study:

  • To review the pathophysiology of COVID-19.
  • To examine the cardiovascular manifestations of COVID-19.
  • To discuss emerging therapeutic strategies for COVID-19.

Main Methods:

  • Literature review of COVID-19 research.
  • Analysis of pathophysiological mechanisms.
  • Synthesis of clinical findings on cardiovascular impact.
  • Compilation of therapeutic prospects.

Main Results:

  • COVID-19 pathophysiology involves hyperinflammation and cytokine storm.
  • Significant cardiovascular manifestations are observed in severe COVID-19.
  • Emerging therapies are being investigated for COVID-19 treatment.

Conclusions:

  • Understanding COVID-19 pathophysiology is crucial for managing severe cases.
  • Cardiovascular complications are a key concern in COVID-19.
  • Ongoing research is vital for developing effective COVID-19 therapeutics.