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COVID-19 and the Heart

Akbarshakh Akhmerov1, Eduardo Marbán1

  • 1From the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.

Circulation Research
|April 8, 2020
PubMed

Insights

Severe COVID-19 causes systemic illness with hyperinflammation and cardiac injury. This review covers COVID-19 pathophysiology, cardiovascular effects, and potential treatments as of April 2020.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathophysiology

Background:

  • Severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) causes COVID-19.
  • Severe COVID-19 presents as a systemic illness with hyperinflammation and cytokine storm.
  • Cardiac injury biomarkers are often elevated in severe COVID-19 cases.

Purpose of the Study:

  • To review the pathophysiology of COVID-19.
  • To examine the cardiovascular manifestations of COVID-19.
  • To discuss emerging therapeutic strategies for COVID-19.

Main Methods:

  • Literature review of COVID-19 research.
  • Analysis of pathophysiological mechanisms.
  • Synthesis of clinical findings on cardiovascular impact.
  • Compilation of therapeutic prospects.

Main Results:

  • COVID-19 pathophysiology involves hyperinflammation and cytokine storm.
  • Significant cardiovascular manifestations are observed in severe COVID-19.
  • Emerging therapies are being investigated for COVID-19 treatment.

Conclusions:

  • Understanding COVID-19 pathophysiology is crucial for managing severe cases.
  • Cardiovascular complications are a key concern in COVID-19.
  • Ongoing research is vital for developing effective COVID-19 therapeutics.

Keywords:
biomarkerscardiovascular diseasescoronavirusinflammationmyocarditis

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