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Screening and identification of circulating miRNA molecular markers in T2DM based on molecular network
Qingsong Zhao1, Yue Gu2, Yanjun Wei2
1The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; The Forth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Abstract:
Type 2 diabetes has become one of the most serious diseases impairing people's life. Circulating miRNAs, involved in the development and progression of type 2 diabetes via different mechanisms, are considered a molecular marker for patients with type 2 diabetes. Based on the expression data of miRNAs in type 2 diabetes from the GEO database, our study screen out 5 differentially expressed candidate miRNAs through the interaction network between miRNAs and target genes and the protein interaction network (PPI) with random walk algorithm. Clinical newly diagnosed diabetic blood was recruited for further PCR experiments. Finally, miR-543 was significantly different, and its expression was up-regulated. miR-543 may become a new marker to bring forth innovation in individualized treatment of diabetes.
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