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Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
Published on: February 9, 2024
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Conformational enhancement of fidelity in toehold-sequestered DNA nanodevices
Antoine Bader1, Scott L Cockroft
1EaStCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh EH9 3FJ, UK. scott.cockroft@ed.ac.uk.
Chemical Communications (Cambridge, England)
|April 8, 2020
Abstract:
The operation of DNA nanodevices is often limited by erroneous strand displacement. Here we demonstrate simple design principles that reduce such leakage by up to two orders of magnitude. Enhanced operational robustness against multiple spurious inputs was obtained by simply relocating toehold overhangs to external locations and strengthening adjacent G-C clamping.
