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Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a

Alessandro Marinaccio1, Dario Consonni, Carolina Mensi

  • 1Epidemiology Unit, Occupational and Environmental Medicine, Epidemiology and Hygiene Department, INAIL, Via Stefano Gradi 55, 00143 Rome, Italy. a.marinaccio@inail.it.

Scandinavian Journal of Work, Environment & Health
|April 8, 2020
PubMed

Insights

Asbestos exposure is linked to rare pericardial and tunica vaginalis testis mesotheliomas. This study confirms asbestos

Area of Science:

  • Oncology
  • Epidemiology
  • Occupational Health

Background:

  • Mesothelioma can affect the pericardium and tunica vaginalis testis.
  • Asbestos exposure is a known cause of mesothelioma.
  • Epidemiology and risk factors for these rare mesotheliomas are not well-defined.

Purpose of the Study:

  • Describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma.
  • Assess the association between asbestos exposure and these rare mesotheliomas.
  • Evaluate prognostic factors for these conditions.

Main Methods:

  • Utilized data from the Italian national mesothelioma registry (ReNaM) from 1993-2015.
  • Calculated incidence rates and median survival periods.
  • Conducted a case-control study to analyze asbestos exposure (occupational and non-occupational).

Main Results:

  • Registered 58 pericardial and 80 tunica vaginalis testis mesothelioma cases.
  • Mean annual incidence rates were 0.049/million (men) and 0.023/million (women) for pericardial, and 0.095/million for tunica vaginalis testis.
  • Occupational asbestos exposure showed a significant association with increased risk (OR 3.68 and 3.42, respectively).
  • Median survival was 2.5 months (pericardial) and 33.0 months (testicular).
  • Age was the primary prognostic factor for both sites.

Conclusions:

  • This study provides the first analytical evidence linking asbestos exposure to pericardial and tunica vaginalis testis mesothelioma.
  • Findings support a causal role of asbestos for all mesothelioma anatomical sites.
  • The extreme rarity, poor survival, and age as a prognostic factor were confirmed.

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