Peyronie's disease: Contemporary evaluation and management

Area of Science:

• Urology
• Andrology
• Regenerative Medicine

Background:

• Peyronie's disease is a prevalent condition involving penile scarring, leading to pain, curvature, and sexual dysfunction.
• It's understood as a disordered wound healing response to penile trauma in genetically susceptible individuals.
• Without intervention, symptoms often persist or worsen, though penile pain may resolve spontaneously.

Purpose of the Study:

• To outline a practical framework for evaluating and managing patients with Peyronie's disease.
• To review current therapeutic options, highlighting their efficacy and limitations.
• To provide guidance on selecting appropriate treatments based on disease severity and stability.

Main Methods:

• Review of existing literature on Peyronie's disease evaluation and management.
• Analysis of various treatment modalities, including oral therapies, traction, injections, surgery, and penile prostheses.
• Discussion of diagnostic criteria and patient assessment strategies.

Main Results:

• No oral therapies are definitively supported as monotherapy for Peyronie's disease.
• Penile traction and intralesional injections offer modest benefits, especially when initiated early.
• Surgical interventions like plication or plaque excision/grafting provide reliable curvature correction in stable disease.
• Penile prostheses effectively manage combined Peyronie's disease and erectile dysfunction with high satisfaction.

Conclusions:

• Management of Peyronie's disease requires a tailored approach based on individual patient factors.
• Surgical options and penile prostheses are effective for established deformities and coexisting erectile dysfunction.
• Further research is needed to establish robust evidence for oral therapies and other non-surgical interventions.